Systemic Anti-Cancer Therapy Regimen Library
UKALL60+ with imatinib Maintenance (LEU ALL BCR-ABL1+ - UKALL60+ with imatinib)
Treatment Overview
Starts after recovery from Consolidation, with neutrophils greater than 0.75 x 109/L and platelets greater than 75 x 109/L.
Cycles 1 to 8 - 90 days
imatinib: Take continuously during treatment, dose reduction may be required based on individual patient tolerability.
mercaptOPURine:
- 25 mg/m2 orally ONCE daily is the starting dose, see Additional details for recommended Dose adjustments to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
- Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Intrathecal metHOTREXATe: For Ommaya reservoir reduce dose to 6 mg intraventricularly.
Cycle details
Cycles 1 to 8 - 90 days
Medication | Dose | Route | Days | Max Duration |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration | 1 to 90 | |
mercaptOPURine * | 25 mg/m² Once daily | oral administration | 1 to 90 | |
prEDNISone | 60 mg/m² Once daily | oral administration | 1 to 5 | |
vinCRISTine | 1.4 mg/m² Cap dose per administration at: 2 mg | intravenous | 1 | 10 minutes |
metHOTREXATe | 12 mg flat dosing | intrathecal injection | 1 |
imatinib: Take continuously during treatment, dose reduction may be required based on individual patient tolerability.
mercaptOPURine:
- 25 mg/m2 orally ONCE daily is the starting dose, see Additional details for recommended Dose adjustments to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
- Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Intrathecal metHOTREXATe: For Ommaya reservoir reduce dose to 6 mg intraventricularly.
Full details
Cycles 1 to 8 - 90 days
Day: 1
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
|
prEDNISone | 60 mg/m² Once daily | oral administration |
Instructions:
Take in the morning with food. |
|
vinCRISTine | 1.4 mg/m² Cap dose per administration at: 2 mg | intravenous | 10 minutes |
Instructions:
|
metHOTREXATe | 12 mg flat dosing | intrathecal injection |
Instructions:
|
Day: 2
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
|
prEDNISone | 60 mg/m² Once daily | oral administration |
Instructions:
Take in the morning with food. |
Day: 3
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
|
prEDNISone | 60 mg/m² Once daily | oral administration |
Instructions:
Take in the morning with food. |
Day: 4
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
|
prEDNISone | 60 mg/m² Once daily | oral administration |
Instructions:
Take in the morning with food. |
Day: 5
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
|
prEDNISone | 60 mg/m² Once daily | oral administration |
Instructions:
Take in the morning with food. |
Day: 6
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 7
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 8
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 9
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 10
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 11
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 12
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 13
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 14
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 15
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 16
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 17
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 18
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 19
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 20
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 21
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 22
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 23
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 24
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 25
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 26
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 27
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 28
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 29
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 30
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 31
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 32
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 33
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 34
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 35
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 36
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 37
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 38
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 39
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 40
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 41
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 42
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 43
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 44
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 45
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 46
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 47
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 48
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 49
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 50
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 51
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 52
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 53
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 54
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 55
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 56
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 57
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 58
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 59
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 60
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 61
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 62
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 63
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 64
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 65
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 66
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 67
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 68
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 69
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 70
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 71
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 72
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 73
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 74
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 75
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 76
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 77
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 78
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 79
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 80
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 81
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 82
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 83
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 84
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 85
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 86
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 87
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 88
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 89
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Day: 90
Medication | Dose | Route | Max duration | Details |
---|---|---|---|---|
imatinib | 600 mg Once daily | oral administration |
Instructions:
|
|
mercaptOPURine * | 25 mg/m² Once daily | oral administration |
Instructions:
Additional details:
|
Additional details
Section 1: Dose adjustments for mercaptOPURine
Supportive Care Factors
Factor | Value |
---|---|
Antiviral prophylaxis for herpes virus: | Routine antiviral prophylaxis recommended |
Constipation risk: | Variable |
Diarrhoea risk: | Variable |
Emetogenicity: | Medium to high |
Gastroprotection: | Gastroprotection is recommended |
Pneumocystis jirovecii pneumonia (PJP) prophylaxis: | Routine antibiotic prophylaxis recommended |
Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.
Constipation/Diarrhoea risk: vinCRISTine may cause constipation and imatinib may cause diarrhoea. Monitor gastrointestinal symptoms.
Emetogenicity: imatinib: MINIMAL to LOW ≤400 mg; MEDIUM to HIGH >400 mg; however, based on New Zealand clinical experience emetogenicity for imatinib doses greater than 400 mg may also only be Minimal to low.
Gastroprotection: Gastroprotective agents are only intended for short term use while patient is receiving corticosteroid treatment doses.
References
REX Medical Limited. Imatinib New Zealand Data Sheet 5 June 2020. https://www.medsafe.govt.nz/profs/datasheet/i/imatinibcap.pdf (Accessed 17 October 2020).
* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.
s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.